药物详细合成路线
| Name | Nimodipine;Bay-e-9736;Periplum;Admon;Nimotop | | Chemical Name | 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) diester | | CAS | 66085-59-4 | | Related CAS | | | Formula | C21H26N2O7 | | Structure |  | | Formula Weight | 418.45057 | | Stage | 上市-1985 | | Company | Bayer (Originator), Esteve (Licensee), Italfarmaco (Licensee) | | Activity/Mechanism | Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Calcium Channel Blockers | | Syn. Route | 1 | | Route 1 | | by cyclocondensation of a mixture of isopropyl(m-nitrobenzylidene)acetylacetate (ii), 2-methoxyethyl acetylacetate (i) and nh3 in refluxing ethanol. | | |  | | List of intermediates | No. | | ethyl 2-cyano-2-(1-methyl-4-piperidinylidene)acetate | (ii) | | (4s)-4-benzyl-3-butyryl-1,3-oxazolidin-2-one | (i) | | | Reference 1: meyer, h.; et al.; unsymmetrical esters of 1,4-dihydropyridine-3,5-dicarboxylic acid. be 0781878; de 2117571; fr 2132830; gb 1358951; us 3799934 . Reference 2: castaner, j.; serradell, m.n.; mealy, n.e.; blancafort, p.; leeson, p.a.; nimodipine. drugs fut 1981, 6, 2, 98. |
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来源:药化网
作者:药化小编
摘要:本文合成路线介绍的是药物中文名尼莫地平；英文名Nimodipine;Bay-e-9736;Periplum;Admon;Nimotop；CAS[66085-59-4]
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