药物详细合成路线

Name	Nimodipine;Bay-e-9736;Periplum;Admon;Nimotop
Chemical Name	1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) diester
CAS	66085-59-4
Related CAS
Formula	C21H26N2O7
Structure
Formula Weight	418.45057
Stage	上市-1985
Company	Bayer (Originator), Esteve (Licensee), Italfarmaco (Licensee)
Activity/Mechanism	Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Calcium Channel Blockers
Syn. Route	1

Route 1 by cyclocondensation of a mixture of isopropyl(m-nitrobenzylidene)acetylacetate (ii), 2-methoxyethyl acetylacetate (i) and nh3 in refluxing ethanol. List of intermediates No. ethyl 2-cyano-2-(1-methyl-4-piperidinylidene)acetate (ii) (4s)-4-benzyl-3-butyryl-1,3-oxazolidin-2-one (i) Reference 1:     meyer, h.; et al.; unsymmetrical esters of 1,4-dihydropyridine-3,5-dicarboxylic acid. be 0781878; de 2117571; fr 2132830; gb 1358951; us 3799934 . Reference 2:     castaner, j.; serradell, m.n.; mealy, n.e.; blancafort, p.; leeson, p.a.; nimodipine. drugs fut 1981, 6, 2, 98.

来源:药化网

作者:药化小编

摘要:本文合成路线介绍的是药物中文名尼莫地平；英文名Nimodipine;Bay-e-9736;Periplum;Admon;Nimotop；CAS[66085-59-4]

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