药物详细合成路线
| Name | Adefovir;GS-0393;GS-393;PMEA | | Chemical Name | 9-[2-(Phosphonomethoxy)ethyl]adenine
[2-(6-Amino-9H-purin-9-yl)ethoxymethyl]phosphonic acid | | CAS | 106941-25-7 | | Related CAS | 118553-11-0 (monoNa salt) | | Formula | C8H12N5O4P | | Structure |  | | Formula Weight | 273.18974 | | Stage | 注册 | | Company | Academy of Sciences of Czech Republic (Originator), Gilead (Licensee) | | Activity/Mechanism | AIDS Medicines, Anti-Hepatitis B Virus Drugs, Anti-Hepatitis Virus Drugs, Anti-HIV Agents, ANTIINFECTIVE THERAPY, Antiviral Drugs, Reverse Transcriptase Inhibitors | | Syn. Route | 1 | | Route 1 | | pmea was prepared by a straightforward route from readily available 2-acetoxyethoxymethyl chloride (i). the key intermediate, diethyl 2-bromoethylmethoxyphosphonate (iv), was coupled with adenine (v) in the presence of sodium hydride, followed by hydrolysis to afford pmea. | | |  | | List of intermediates | No. | | 1-iodo-4-nitrobenzene | (v) | | methyl (2r,3r,4s)-4-(1,3-benzodioxol-5-yl)-2-(3-fluoro-4-methylphenyl)-3-pyrrolidinecarboxylate | (vi) | | | (ii) | | | (iii) | | | (iv) | | | Reference 1: hwang, j.-t.; choi, j.-r.; novel phosphonate nucleosides as antiviral agents. drugs fut 2004, 29, 2, 163. |
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来源:药化网
作者:药化小编
摘要:本文合成路线介绍的是药物中文名阿德福韦；英文名Adefovir;GS-0393;GS-393;PMEA；CAS[106941-25-7]
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