药物详细合成路线
| Name | Butenafine hydrochloride;501 cream(combination with betamethasone dipropionate);KP-363;Volley;Mentax | | Chemical Name | N-Methyl-N-(4-tert-butylbenzyl)-1-naphthylmethylamine hydrochloride
4-tert-Butyl-N-methyl-N-(1-napthylmethyl)benzylamine hydrochloride | | CAS | 101827-46-7 | | Related CAS | 101828-21-1 (free base) | | Formula | C23H28ClN | | Structure |  | | Formula Weight | 353.93931 | | Stage | 上市-1992 | | Company | Kaken (Originator), Bertek (Licensee), Schering-Plough (Licensee), UCB (Licensee), Hisamitsu (Formulation) | | Activity/Mechanism | Antifungal Agents, ANTIINFECTIVE THERAPY | | Syn. Route | 2 | | Route 1 | | by condensation of n-methyl-1-naphthylmethylamine (i) with 4-(tert-butyl)benzyl bromide (ii) by means of na2co3 in dmf, followed by acidification with hcl in ethanol. | | |  | | List of intermediates | No. | | 2-methoxy-2-methylpropylformamide | (i) | | methyl 5-chloro-2-nitrobenzoate | (ii) | | | Reference 1: arai, k.; arita, m.; sedino, t.; komoto, n.; hirose, s. (mitsui toatsu chem.; inc.); benzylamine derivatives, process for production thereof, and use thereof. ep 0221781 . Reference 2: prous, j.; castaner, j.; kp-363. drugs fut 1989, 14, 4, 315. |
Route 2 | | by condensation of 1-(chloromethyl)naphthalene (i) with n-(4-tert-butylbenzyl)-n-methylamine (ii) by means of sodium carbonate in hot dmf. | | |  | | List of intermediates | No. | | benzhydryl (6r,7s)-3-[(acetoxy)methyl]-7-amino-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | (i) | | methyl 8-bromooctanoate | (ii) | | | Reference 1: maeda, t.; koshikawa, s.; yamamoto, t.; sasaki, k.; yokoo, m.; amemiya, k.; hashimoto, r.; arika, t.; takase, m. (kaken pharmaceutical co., ltd.); amine derivs. and fungicides containing the same. us 5021458 . |
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来源:药化网
作者:药化小编
摘要:本文合成路线介绍的是药物中文名盐酸布替萘芬；英文名Butenafine hydrochloride;501 cream(combination with betamethasone dipropionate);KP-363;Volley;Mentax；CAS[101827-46-7]
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