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药物详细合成路线

Name Miglitol;SK-983;Bay-m-1099;Plumarol;Diastabol;Glyset
Chemical Name 1,5-Dideoxy-1,5-[(2-hydroxyethyl)imino]-D-glucitol
      (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol
CAS 72432-03-2
Related CAS
Formula C8H17NO5
Structure
Formula Weight 207.22839
Stage 上市-1998
Company Bayer (Originator), Lacer (Licensee), Pfizer (Licensee), Sanofi-synthélabo (Licensee), Sanwa (Licensee)
Activity/Mechanism Antidiabetic Drugs, ENDOCRINE DRUGS, Type 2 Diabetes Mellitus, Agents for, alpha-Glucosidase Inhibitors, Iminosugars
Syn. Route 1
Route 1
a new synthesis of miglitol has been reported:reaction of the bromoglycoside (i) with ethanolamine (ii) by means of zn and nabh3cn in refluxing propanol/water gives the adduct (iii), which is benzylated with benzyl chloride and nah in dmf yielding compound (iv). the cyclization of (iv) by means of mercury