药物详细合成路线
| Name | Miglitol;SK-983;Bay-m-1099;Plumarol;Diastabol;Glyset | | Chemical Name | 1,5-Dideoxy-1,5-[(2-hydroxyethyl)imino]-D-glucitol
(2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol | | CAS | 72432-03-2 | | Related CAS | | | Formula | C8H17NO5 | | Structure |  | | Formula Weight | 207.22839 | | Stage | 上市-1998 | | Company | Bayer (Originator), Lacer (Licensee), Pfizer (Licensee), Sanofi-synthélabo (Licensee), Sanwa (Licensee) | | Activity/Mechanism | Antidiabetic Drugs, ENDOCRINE DRUGS, Type 2 Diabetes Mellitus, Agents for, alpha-Glucosidase Inhibitors, Iminosugars | | Syn. Route | 1 | | Route 1 | | a new synthesis of miglitol has been reported:reaction of the bromoglycoside (i) with ethanolamine (ii) by means of zn and nabh3cn in refluxing propanol/water gives the adduct (iii), which is benzylated with benzyl chloride and nah in dmf yielding compound (iv). the cyclization of (iv) by means of mercury | | |
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