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有机人名反应:Wacker-Tsuji Oxidation
2011-03-05 21:18:38 来源:不详 浏览:5733
Wacker-Tsuji Oxidation

The Wacker Oxidation is an industrial process, which allows the synthesis of ethanal from ethene by palladium-catalyzed oxidation with oxygen. Copper serves as redox cocatalyst.

The lab scale modification - the Wacker-Tsuji Oxidation - is useful for the synthesis of various ketones.


Mechanism of the Wacker-Tsuji Oxidation

The mechanism is typical of palladium olefin chemistry, and water serves as the oxygen source; the reduced palladium is reoxidized by Cu(II) and ultimately by atmospheric oxygen.

J. Tsuji, "Palladium Reagents and Catalysts", First Edition 2004, Wiley, 29-35.

Recent Literature


Discovery of a Practical Direct O2-Coupled Wacker Oxidation with Pd[(-)-sparteine]Cl2
C. N. Cornell, M. S. Sigman, Org. Lett., 2006, 8, 4117-4120.


Convenient and Efficient Pd-Catalyzed Regioselective Oxyfunctionalization of Terminal Olefins by Using Molecular Oxygen as Sole Reoxidant
T. Mitsudome, T. Umetani, N. Nosaka, K. Mori, T. Mizugaki, K. Ebitani, K. Kaneda, Angew. Chem. Int. Ed., 2006, 45, 481-485.


Multifunctional Palladium Catalysis. 2. Tandem Haloallylation Followed byWacker-Tsuji Oxidation or Sonogashira Cross-Coupling
A. N. Thadani, V. H. Rawal, Org. Lett., 2002, 4, 4321-4323.


A General and Efficient Catalyst System for a Wacker-Type Oxidation Using TBHP as the Terminal Oxidant: Application to Classically Challenging Substrates
B. W. Michel, A. M. Camelio, C. N. Cornell, M. S. Sigman, J. Am. Chem. Soc., 2009, 131, 6076-6077.


Multicatalytic Processes Using Diverse Transition Metals for the Synthesis of Alkenes
H. Lebel, V. Paquet, J. Am. Chem. Soc., 2004, 126, 11152-11153.


Wacker-Type Oxidation of Alkynes into 1,2-Diketones Using Molecular Oxygen
W. Ren, Y. Xia, S.-J. Ji, Y. Zhang, X. Wan, J. Zhao, Org. Lett., 2009,11, 1841-1844.


A Facile Synthesis of 2-Methylquinolines via Pd-Catalyzed Aza-Wacker Oxidative Cyclization
Z. Zhang, J. Tang, Z. Wang, Org. Lett., 2008,10, 173-175.


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