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有机人名反应:Barton-McCombie ReactionBarton Deoxygenation
2011-03-05 20:43:27 来源:不详 浏览:11881
Barton-McCombie Reaction
Barton Deoxygenation

A method for the deoxygenation of alcohols. The alcohol is first converted to the thiocarbonyl derivative, and is then treated withBu3SnH. Once the radical chain has been initiated, attack on the Bu3Sn carrier by sulphur initiates a decomposition yielding the alkyl radical, for which Bu3SnH serves as hydrogen radical (H) donor. The driving force for the reaction is the formation of the very stable S-Sn bonds.


Mechanism of the Barton-McCombie Reaction

Initiation:

The catalytic cycle, in which low concentration of .SnBu3effects the reaction:

Recent Literature


A Tin Hydride Designed To Facilitate Removal of Tin Species from Products of Stannane-Mediated Radical Reactions
D. L. J. Clive, J. Wang, J. Org. Chem., 2002, 67, 1192-1198.


Radical Reactions in Aqueous Medium Using (Me3Si)3SiH
A. Postigo, S. Kopsov, C. Ferreri, C. Chatgilialoglu, Org. Lett., 2007,9, 5159-5162.


Radical-based transformation of vicinal diols to olefins via thioxocarbamatederivatives: a simple approach to 2',3'-didehydro-2',3'-dideoxynucleosides
M. Oba, M. Suyama, A. Shimamura, K. Nishiyama, Tetrahedron Lett., 2003, 44, 4027-4029.


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