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有机合成中的还原剂:Manganese
2011-03-07 21:54:48 来源:不详 浏览:1754
Manganese

Name Reactions


Nozaki-Hiama-Kishi Coupling


Recent Literature


An efficient, nickel-catalyzed direct reductive cross-coupling of equimolar amounts of alkyl halides with aryl halides in the presence of manganese is generally high-yielding, highly functional-group-tolerant, and easy to perform. The reaction appears to avoid the formation of intermediate organomanganese species, and a synergistic effect was found when a mixture of two ligands was employed.
D. A. Everson, R. Shrestha, D. J. Weix, J. Am. Chem. Soc., 2010, 132, 920-921.


A generally applicable, sequential reaction of dichloroesters with various aldehydes is promoted by active manganese to give α,β-unsaturated esters with complete control of stereoselectivity. The C-C double bond can be di- or trisubstituted. A mechanism based on a successive aldol-type reaction/-elimination is proposed.
J. M. Concelln, H. Rodrquez-Solla, P. Daz, R. Llaona, J. Org. Chem., 2007,72, 4396-4400.


A complete E-selective synthesis of α,β-unsaturated amides through a sequential reaction of a range of dichloroamides with a variety of aldehydes is promoted by Rieke manganese (Mn*). The unsaturated amides obtained are readily and efficiently transformed into α,β-unsaturated ketones, aldehydes, or carboxylic acids.
J. M. Concelln, H. Rodrquez-Solla, P. Daz, J. Org. Chem., 2007,72, 7974-7979.


Stereoselective β-elimination of diastereomeric mixtures of 2-bromo-3-hydroxyesters is achieved by using unactivated manganese and trimethylsilyl chloride, to yield (E)-α,β-unsaturated esters with total diastereoselectivity.
J. M. Concelln, H. Rodrguez-Solla, V. del Amo, Synlett, 2006, 315-317.


A totally regioselective transformation of aromatic N-4-methoxyphenylaziridine 2-carboxamides into 2-aminoamides is promoted by active manganese (Mn*). α-Amino ketones can be readily obtained by reaction of morpholine-derived 2-aminoamides with organolithium compounds.
J. M. Concelln, H. Rodrguez-Solla, V. del Amo, P. Daz, J. Org. Chem., 2010,75, 2407-2410.

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